Modified immune cells seek and destroy melanoma

Public release date: 24-Jun-2013
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Contact: Jillian Hurst
press_releases@the-jci.org
Journal of Clinical Investigation

In this issue of the Journal of Clinical Investigation, researchers led by Scott Pruitt at Duke University and Merck Research Laboratories report on a human clinical trial in which modified dendritic cells, a component of the immune system, were tested in patients with melanoma. All cells express a complex known as the proteasome, which acts as the garbage disposal for the cell. There are two types of proteasomes: constitutive proteasomes (cPs), which are found in normal tissues, and immunoproteasomes (iPs), which are found in stressed or damaged cells. In a damaged cell, the iP generates protein fragments that are displayed on the surface of the distressed cells, triggering recognition by dendritic cells and subsequent destruction by the immune system.

Most cancers, including melanoma, exclusively express cPs, making it impossible for them to express the protein fragments that are recognized by the immune system. To make it easier for the immune system to find cancer cells, Pruitt and colleagues engineered a specific type of immune cell, known as a dendritic cell, that recognizes protein fragments of cancer specific antigens made by cPs. The engineered dendritic cells were then injected into patients that were in remission from melanoma.

The trial consisted of 4 patients that were vaccinated with regular dendritic cells, 3 patients that received cells that underwent a control treatment, and 5 patients that received dendritic cells that recognized cancer-made protein fragments. Vaccination with all three types of dendritic cells elicited an immune response, which peaked after 3-4 vaccinations with dendritic cells. Patients that received the specially modified dendritic cells had a longer lasting immune response and fewer circulating melanoma cells. Of the two patients that had active disease, treatment with modified dendritic cells resulted in a partial clinical response in one and a complete clinical response in the other.

These results suggest that modification of dendritic cells so that they recognize cP-produced tumor antigens enhances immune recognition of melanoma cells.

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This study was funded by Duke Clinical Research Institute/Duke Translational Medicine Institute, Duke Melanoma Consortium, and Duke University Department of Surgery. Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, etc.

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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Public release date: 24-Jun-2013
[ | E-mail | Share ]

Contact: Jillian Hurst
press_releases@the-jci.org
Journal of Clinical Investigation

In this issue of the Journal of Clinical Investigation, researchers led by Scott Pruitt at Duke University and Merck Research Laboratories report on a human clinical trial in which modified dendritic cells, a component of the immune system, were tested in patients with melanoma. All cells express a complex known as the proteasome, which acts as the garbage disposal for the cell. There are two types of proteasomes: constitutive proteasomes (cPs), which are found in normal tissues, and immunoproteasomes (iPs), which are found in stressed or damaged cells. In a damaged cell, the iP generates protein fragments that are displayed on the surface of the distressed cells, triggering recognition by dendritic cells and subsequent destruction by the immune system.

Most cancers, including melanoma, exclusively express cPs, making it impossible for them to express the protein fragments that are recognized by the immune system. To make it easier for the immune system to find cancer cells, Pruitt and colleagues engineered a specific type of immune cell, known as a dendritic cell, that recognizes protein fragments of cancer specific antigens made by cPs. The engineered dendritic cells were then injected into patients that were in remission from melanoma.

The trial consisted of 4 patients that were vaccinated with regular dendritic cells, 3 patients that received cells that underwent a control treatment, and 5 patients that received dendritic cells that recognized cancer-made protein fragments. Vaccination with all three types of dendritic cells elicited an immune response, which peaked after 3-4 vaccinations with dendritic cells. Patients that received the specially modified dendritic cells had a longer lasting immune response and fewer circulating melanoma cells. Of the two patients that had active disease, treatment with modified dendritic cells resulted in a partial clinical response in one and a complete clinical response in the other.

These results suggest that modification of dendritic cells so that they recognize cP-produced tumor antigens enhances immune recognition of melanoma cells.

###

This study was funded by Duke Clinical Research Institute/Duke Translational Medicine Institute, Duke Melanoma Consortium, and Duke University Department of Surgery. Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, etc.

---

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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Source: http://www.eurekalert.org/pub_releases/2013-06/joci-mic061713.php

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Car bombs kill dozens in Baghdad

BAGHDAD (Reuters) - Ten car-bomb explosions killed at least 39 people across the Iraqi capital on Monday, police and medical sources said.

In the central district of Karada, two parked car bombs went off killing at least eight people, and another two car bombs exploded simultaneously near a market in the western district of Jihad, killing eight.

Violence has been increasing in Iraq in recent months, with more than 1,000 people killed in May alone, making it the deadliest month since the sectarian bloodletting of 2006-07.

Insurgents including al Qaeda's Iraqi affiliate have been regaining ground and recruits from the country's Sunni minority, which feels sidelined since the U.S.-led invasion toppled former dictator Saddam Hussein and empowered majority Shi'ites.

Sectarian tensions in Iraq and the wider region have been inflamed by the civil war in Syria, where mainly Sunni Muslim rebels are fighting to overthrow President Bashar al-Assad, whose Alawite sect derives from Shi'ite Islam.

(Reporting Kareem Raheem and Suadad al-Salhy; Writing by Isabel Coles; Editing by Michael Roddy)

Source: http://news.yahoo.com/seven-bomb-blasts-kill-27-people-iraqi-capital-170556994.html

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Fire rages, Colo. town braces for long evacuation

DEL NORTE, Colo. (AP) ? A colossal wildfire near a popular summer retreat in southern Colorado continues to be driven by winds and fueled by dead trees in a drought-stricken area, authorities said Sunday.

The weather has prevented fire crews from making progress on the blaze, which grew overnight to 108 square miles, up from 100 on Saturday. The speed with which the fire has spread is exceptional: It was just below 50 square miles Friday evening.

No structures have been lost in the fire, and no injuries have been reported.

It is doubtful fire crews could establish any containment lines until there's a break in the weather, possibly Tuesday, officials said. They remained optimistic they can protect the town, however.

As of Sunday, officials firefighters remained focused on protecting South Fork, the Wolf Creek ski area and homes along Highway 149.

Crews hoped to get aircraft up to drop water over the fire before afternoon winds of 30 to 40 miles an hour returned Sunday. Pete Blume, a commander with the Rocky Mountain Type 1 Incident Command Team, said the wildfire is the worst ever known to hit the Rio Grande National Forest.

"It's not typical to have these kinds of fires here," said Blume. "But beetle kill and drought is also not the norm."

Firefighters are hoping for a break in the high winds as well as the anticipated July monsoons to help them fight back the flames. Until then, Blume said, "with that much beetle kill and drought we could have every resource in the country here and still not put in a containment line."

Still, fire officials believe portions of the blaze will likely burn all summer in forested, nonresidential areas, with full extinguishment probably months away.

The lightning-sparked blaze started June 5, but its rapid advance Friday prompted the evacuation of hundreds of visitors and the town's 400 permanent residents.

Residents and tourists were settling in for a long wait before they can return to their homes, cabins and RV parks.

"They just said they had no idea how long it would be before we could back in South Fork," said Mike Duffy, who owns the South Fork Lodge.

Duffy said he and his wife, Mary, were able to get their personal possessions before fleeing fast-advancing flames that officials initially feared would overtake the town. But with the fire still within three miles of South Fork, they are worried about the long-term impact of a prolong evacuation and news reports about the fire raging around the tourism-dependent town.

Summer visitors include many retirees from Texas and Oklahoma who come to the mountains to flee the heat.

South Fork Mayor Kenneth Brooke estimates that between 1,000 to 1,500 people had to flee, including the summer visitors and permanent residents.

More than 600 firefighters were battling the blaze, and more are coming every day. They also focused on newest arm of the fire as it crept through beetle kill toward the historic mining town of Creede, the last silver boom town in Colorado before the industry went bust in the late 1800s.

Elsewhere in Colorado, about a dozen fires also continued to burn. Firefighters were making progress on a 19-square-mile wildfire near Walsenburg in southern Colorado. The fire was 10 percent contained.

And a wildfire in foothills about 30 miles southwest of Denver was expected to be fully contained Sunday evening. That fire burned 511 acres and forced 100 people to leave their homes.

Source: http://news.yahoo.com/fire-rages-colo-town-braces-long-evacuation-192730333.html

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Jim Carrey 'Cannot Support' 'Kick-Ass 2' After Sandy Hook

Carrey tweeted that he's had a 'change of heart' about the August sequel, prompting creator Mark Millar to respond.
By Jocelyn Vena

Actor Jim Carrey attends Jane Fonda's hand and footprint ceremony at TCL Chinese Theatre on April 27, 2013 in Hollywood, California.
Photo: Getty Images

Source: http://www.mtv.com/news/articles/1709455/jim-carrey-kick-ass-2-sandy-hook.jhtml

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Snowden to Face Espionage Charges (ABC News)

Share With Friends: | | Politics - Top Stories News, News Feeds and News via Feedzilla.

Source: http://news.feedzilla.com/en_us/stories/politics/top-stories/314421673?client_source=feed&format=rss

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Nelson Mandela's condition now 'critical'

After spending a few days roasting over an open fire, Paula Deen is cooked. She lost her job with the Food Network on Friday meaning that she is, for all intents and purposes, gone from our lives now. But an unusual voice spoke up in her defense last night: professional opinioner Bill Maher. Eater pointed us towards this video of Maher defending the former Food Network star on last night's?Real Time with Bill Maher. ...

Source: http://news.yahoo.com/ex-president-mandelas-condition-now-critical-government-195941217.html

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Obama to nominate McSweeny to Federal Trade Commission

WASHINGTON (Reuters) - President Barack Obama plans to nominate Terrell McSweeny, a veteran of Vice President Joe Biden's staff, to be a commissioner on the Federal Trade Commission, the White House said on Friday.

McSweeny, now chief counsel for competition policy at the Justice Department's antitrust division, would fill a Democratic slot on the five-member commission, which enforces antitrust law and laws against deceptive advertising.

The FTC normally has five commissioners, and no more than three can be from the same party.

The current vacancy was created when Edith Ramirez, a law school classmate of Obama and a Democrat, was elevated to the chairmanship after Jon Leibowitz departed in February.

The commission's other Democrat is Julie Brill. Rounding out the group are Republicans Maureen Ohlhausen and Joshua Wright.

The position requires Senate confirmation.

Because of the vacancy, there has been concern about deadlocks leading to inaction. In the case of a 2-2 vote by commissioners, the FTC takes no action.

The commission is in the process of considering several key mergers, including the proposed Office Depot Inc deal to buy rival OfficeMax Inc; and the television ratings company Nielsen Holdings NV plan to buy Arbitron Inc, which dominates radio ratings.

(Reporting by Diane Bartz and Jeff Mason; Editing by Xavier Briand)

Source: http://news.yahoo.com/obama-nominate-mcsweeny-federal-trade-commission-232806425.html

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British spy agency taps cables, shares with NSA: Guardian

LONDON (Reuters) - Britain's spy agency GCHQ has tapped fiber-optic cables that carry international phone and internet traffic and is sharing vast quantities of personal information with the U.S. National Security Agency, the Guardian newspaper said on Friday.

The paper, which has in recent weeks been publishing details of top-secret surveillance programs exposed by former NSA contractor Edward Snowden, said on its website that Snowden had shown it documents about a project codenamed "Tempora."

Tempora has been running for about 18 months and allows GCHQ, which stands for Government Communications Headquarters, to tap into and store huge volumes of data drawn from fiber-optic cables for up to 30 days, the paper said.

The Guardian said Snowden had provided it with access to documents about GCHQ's alleged cable-tapping operation as part of his effort to expose "the largest program of suspicionless surveillance in human history."

For decades, the NSA and GCHQ have worked as close partners, sharing intelligence under an arrangement known as the UKUSA agreement. They also collaborate with eavesdropping agencies in Canada, Australia and New Zealand under an arrangement known as the "Five Eyes" alliance.

The latest Guardian story will likely put more pressure on British Prime Minister David Cameron's government to reassure the public about how data about them is collected and used.

Earlier this month, in response to questions about the secret U.S. data-monitoring program Prism, British Foreign Secretary William Hague told Parliament that GCHQ always adhered to British law when processing data gained from eavesdropping.

He would not confirm or deny any details of UK-U.S. intelligence sharing, saying that to do so could help Britain's enemies.

"In line with long-standing practice we do not comment on intelligence matters," a GCHQ spokesman said on Friday.

NSA spokeswoman Judith Emmel rejected any suggestion the U.S. agency used the British to do things the NSA cannot do legally. Under U.S. law, the NSA must get authorization from a secret federal court to collect information either in bulk or on specific people.

"Any allegation that NSA relies on its foreign partners to circumvent U.S. law is absolutely false. NSA does not ask its foreign partners to undertake any intelligence activity that the U.S. government would be legally prohibited from undertaking itself," Emmel said.

INTERCEPT PROBES

The Tempora operation involves attaching intercept probes to transatlantic cables where they land on British shores from North America, the Guardian said.

That was done with the agreement of unnamed companies, which were forbidden from revealing warrants that compelled them to allow GCHQ access, it added.

Snowden made world headlines earlier this month when he provided details of NSA surveillance programs to the Guardian and the Washington Post.

In Washington, Snowden's disclosures have ignited a political storm over the balance between privacy rights and national security, but the NSA has defended the programs, saying they have disrupted possible attacks.

In the wake of Snowden's revelations, U.S. officials acknowledged that the NSA, with cooperation from internet and telephone companies, collected email on foreign intelligence suspects, including counterterrorism targets, as well as masses of raw data on calls made within the United States and overseas by subscribers to major telephone companies.

The content of messages of people in the United States - including U.S. citizens - sometimes are intercepted "incidentally," officials have said, but rules require such intercepts to be purged unless U.S. authorities get court authorization.

(Reporting by Rosalba O'Brien and Michael Holden in London and Mark Hosenball in Washington; Editing by Andrew Roche and Peter Cooney)

Source: http://news.yahoo.com/british-spy-agency-taps-cables-shares-nsa-guardian-181011320.html

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Ore. agency blames pesticide for bumble bee kill

WILSONVILLE, Ore. (AP) ? Oregon officials say a pesticide is to blame for the deaths of tens of thousands of bumble bees in a shopping center parking lot southwest of Portland.

The state Department of Agriculture said Friday that tests on bees and foliage showed the deaths are "directly related to a pesticide application on linden trees" that was meant to control aphids.

It said an investigation is under way to see if the application of the pesticide Safari, done last Saturday, violated the law.

The Oregonian reports that the Agriculture Department, the City of Wilsonville, neighboring towns and some local landscape contractors have covered the sprayed trees with netting in an effort to prevent further insect deaths.

The Xerces (ZERK'-zees) Society for Invertebrate Conservation has upped its estimate of the bee kill to 50,000. Spokesman Scott Black calls that a very conservative number.

___

Information from: The Oregonian, http://www.oregonlive.com

Source: http://news.yahoo.com/ore-agency-blames-pesticide-bumble-bee-kill-184748447.html

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Walk-Through Metal Detectors Were Invented to Catch Thieving Employees

Today we walk through metal detectors to get into courthouses, airports, and even concert venues. But back in the 1920s the first walk-through metal detectors weren't invented for finding weapons (or nail clippers), they were invented for searching would-be thieves.

Primitive handheld metal detectors date back to the 19th century, but it wasn't until the 1920s that two scientists in Germany devised a way to search factory workers for stolen machine parts without having to frisk every employee one by one. Little did they realize that it would be the wave of the future.

In the mid-1920s, H. Geffchen and H. Richter of Leipzig invented the walk-through metal detector ? their "radio detective" ? for a large manufacturing plant in Germany. Without any physical contact, their invention made "an effective search of every person leaving the premises" and determined "with certainty, and instantaneously, whether he is carrying with him any object of a metallic nature."

No more troublesome pat-downs that waste time and leave room for error. Now your employer-sponsored humiliation can be quick and automatic!

The April 1926 issue of Radio News magazine ran an illustration of the device on their cover, which proclaimed, "Radio Oscillator Detects Thieves." The magazine explained that workers were sent through the machine single-file as an attendant wearing headphones looked on, listening for the metal detector to alarm.

In the illustration which accompanies this article, the apparatus with the amplifiers which produce the audio-frequency oscillations is shown at the right, standing on the window ledge. The attendant beside it wears the telephone headset, which is connected to the two circuits as described, and notes the change of sound, if any, as each man passes. The degree of sensitiveness to the presence of metal, attained by the use of this apparatus, is astonishing.

The author of the article for Radio News noted that even the smallest metallic objects are picked up by the Germans' invention:

Even watches and keys can be detected with certainty; in practice the apparatus would be set to an adjustment a little less than critical, so that the smaller bits of metal need not cause signals in the phones. In order to prevent the purpose of the detector being defeated by the presence of lunch cans, thermos flasks, or other property of the workmen, a shelf is provided at the side of the wicket, as shown. The employee leaves any metal articles before passing through the wicket; and then returns to get them, before leaving through the main gate.

The article goes on to explain that if the metal detector is set off, the attendant will use a small handheld "searching coil" on the individual to determine if he's hiding something. Pat-downs were promised to become a thing of the past with such futuristic technology!

If the detector shows the presence of an undue amount o f metal on a person passing through the gate, he maybe then searched with more care. A small "searching coil" is provided for this purpose, which acts on a similar principle to the larger circuit. By moving this coil over the body of the person searched, the location of any piece of metal is determined accurately in an instant. This auxiliary coil may be made so sensitive that it will respond with certainty not only to coins in the pockets, but also to the presence of a stickpin in the cravat or of metal fillings in the teeth; and that without actually coming in contact with the person thus searched.

But this wasn't the first time suspicious employers harnessed the latest technological wizardy to inspect their employees. Back in 1919, a South African diamond mine started using X-rays to search their workers for any diamonds they may have hidden in body cavities or even inside self-inflicted cuts.

So I guess the next time you're going through airport security, just let the TSA agents know that while their inspection may seem intrusive to you, it's really no worse than Germany in the 1920s or South Africa in the 1910s. Trust me, it'll go over well.

Images: scanned from the April 1926 issue of Radio News magazine

Source: http://paleofuture.gizmodo.com/walk-through-metal-detectors-were-invented-to-catch-thi-520336775

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Revival of Paintings on Display at Women's Museum

Wearing gold-sequined Uggs, a bright smile and flawless brown skin that belies her 82 years, Faith Ringgold explains her "confrontational art" ? vivid paintings whose themes of race, gender, class and civil rights were so intense that for years, no one would buy them.

"I didn't want people to be able to look, and look away, because a lot of people do that with art," Ringgold said. "I want them to look and see. I want to grab their eyes and hold them, because this is America."

Look away they did. And they walked away. So Ringgold tucked the paintings out of public view, where they stayed for more than 40 years.

Now, Ringgold's early works are enjoying a revival. They go on display Friday in a new exhibit in the nation's capital.

"American People, Black Light: Faith Ringgold's Paintings of the 1960s," is on display at the National Museum of Women in the Arts until Nov. 10. The exhibit includes 49 paintings from her "American People" and "Black Light" series of the 1960s and 1970s, along with earlier works and political posters created for activist Angela Davis and for efforts in support of the Black Panthers and the 1971 Attica prison riot.

"I'm very happy and very pleased that this work is getting another chance to be seen and heard and that the American people are getting another chance to take a look at themselves," Ringgold said in an interview. "Most of that work I still own because people just didn't want to look at it. They didn't want to see it."

Some works from the "American People" series were first shown at New York's Spectrum Gallery in 1967. Those and other paintings re-emerged beginning in 2010 at the Neuberger Museum of Art in Purchase, N.Y., then at Spelman College Museum of Fine Art in Atlanta and the Miami Art Museum before making their way to the women's museum.

A Harlem native best known for reviving the popularity of African-American story quilts 30 years ago, Ringgold said she created the paintings in response to the civil rights and feminist movements. Ringgold was actively involved in both; she championed displaying artwork by blacks and women, and protested outside the Whitney Museum and Museum of Modern Art in New York in the 1960s and '70s.

The former University of California and New York public school educator said some cultural topics ? like race and gender inequality ? often resurface in cycles.

"A lot of these issues have still not been addressed," she said. "This is typical, kind of ? when there is a problem ? the group that has the issue rises to the occasion and speaks out and there are some parts that are addressed and then when you look around, we're right back where we started. ... Throughout the history of the United States, this has been what has happened."

Paintings from the "American People" series are vibrant and colorful, drawing influences from pop art and traditional African artwork, and depicting a variety of races ? along with how they interact with each other in many of the pieces.

Ringgold's mural "The Flag is Bleeding" depicts a white man, white woman and black man linking arms and standing before an American flag splattered with blood, because of race riots common during that time.

Source: http://abcnews.go.com/US/wireStory/revival-paintings-display-womens-museum-19453370

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3M Mobile Projector MP300

The 3M Mobile Projector MP300 is my new poster child for products that just miss getting everything right. It's small, lightweight, bright, physically attractive, and easy to set up. But it's limited to a single connector?an MHL-enabled HDMI port?which makes it a great choice if you can take advantage of the connector, and completely useless if you can't.

The single-port design isn't quite as limiting as it might seem. In addition to letting you connect to image sources with HDMI, Mini-HDMI, and Micro-HDMI connectors, it also lets you connect, using appropriate adaptors, to sources with an Apple Lightning port, a DisplayPort, a DVI-I or DVI-D port, or an MHL-enabled micro USB port, which includes any number of smartphones and tablets. You can even plug in the Roku Stick that we reviewed late last year. In fact, 3M sells the identical projector with the Roku Stick included, as the 3M Streaming Projector ($300 street).

A major catch, of course, is that the choices don't include either a VGA connector, which is still the ubiquitous choice for Windows computers, or support for USB direct display, which would be a good alternative. Also notable for its absence is a USB A connector that would let you plug in a USB memory key as an image source. That said, however, if you have an image source with a connector you can use, the projector can do an impressive job.

Basics and Setup
The MP300 scores well on portability. It measures roughly 2.0 by 4.3 by 4.2 inches (HWD), but seems smaller, because of rounded edges and tapering, and it weighs just 11 ounces complete with its rechargeable battery. Even with the power block, the total weight is only one pound one ounce. However, you may well choose to leave the power block at home, thanks to a long battery life, at a claimed three and a half hours in Eco mode or two and a half hours in Standard mode.

Like most projectors in its weight class, the MP300 is built around a DLP chip and LED light source, with the light source meant to last the life of the unit. The company rates it at 20,000 hours. The native resolution is WVGA (854 by 480), with input resolutions limited to standard video, rather than common computer, resolutions, at 480p (640 by 480p and 720 by 480p), 576p (720 by 576p), 720p (1280 by 720p), and 1080i (1920 by 1080i and 1440 by 1080i).

Setup is simple. Plug in a cable, point the projector at whatever you're using as a screen, and focus the image. As is typical for projectors this size, there's no zoom control, which means you have to move the projector to adjust image size. The focus control earns special mention for being much easier to adjust than with most small projectors.

One potential problem is that although the MP300 comes with an HDMI to HDMI cable, it doesn't come with any adaptors for other ports, and 3M doesn't sell any. That means you'll have to get them elsewhere, which can be more of a problem than you might think.

The connector is on the back of the unit inside a small depression and facing sideways. The positioning lets you plug in a cable?or a Roku Stick?and then close the back cover without anything sticking out behind the MP300. Unfortunately, the limited clearance between the edge of the connector and the body of the projector can get in the way.

In addition to the HDMI to HDMI cable that comes with the projector, I tried four different cables with an HDMI connector on one end and found that two of them wouldn't seat properly. This would be less of an issue if 3M also included, or at least sold, cables and adaptors that were guaranteed to fit, but it doesn't. For my tests, I connected the projector to a Blu-ray player, using one of the HDMI to HDMI cables that fit properly.

Brightness and Image Quality
The MP300 is rated at 60 lumens. That's less than some other, slightly heavier, LED-based portable projectors, like the 300-lumen Editors' Choice 3M Mobile Projector MP410, and it's a lot less than typical projectors that use standard lamps, like the 2,800-lumen Editors' Choice Epson EX3212 SVGA 3LCD Projector that I recently reviewed. As I've pointed out in other reviews, however, perception of brightness is logarithmic, so if one projector offers one fifth as many lumens as another projector, you'll perceive it is as being far more than one fifth as bright.

Based on The Society of Motion Picture and Television Engineers (SMPTE) recommendation for image brightness, a 60-lumen image using a 1.0 gain screen is suitable for a 30 to 41-inch diagonal image at a 16:9 aspect ratio in theater dark lighting, or a roughly 20-inch image with moderate ambient light. For my tests, however, I found the MP300 usable for long sessions at slightly larger sizes as well, settling on a 41-inch wide (46-inch diagonal) image as bright enough for comfortable viewing.

With no VGA port on the MP300, I couldn't run our standard suite of data image tests. However, the projector scored impressively well on our video tests, despite the low native resolution putting some obvious limits on its ability to show fine detail.

It did an excellent job resisting posterization (shading changing suddenly where it should change gradually) and a good job with shadow detail (details based on shading in dark areas), even in scenes that tend to cause those problems. It also did a good job with skin tones, and showed only a minimal level of noise. The quality was certainly good enough to be comfortable to watch for long sessions.

Rainbows and Other Issues
Rainbow artifacts, with light areas breaking up into little red-green-blue rainbows, are always a potential concern for any single-chip DLP projector. Even though I see these artifacts easily, however, I saw very few with most test clips with the MP300. The exception was with a black and white clip, where they showed often enough to be annoying. Even so, unless you're planning to watch black and white movies or old TV shows, it's unlikely that you'll find the rainbow artifacts bothersome.

Also demanding mention is the MP300's 2-watt speaker. As with the sound systems in most small projectors, it's essentially useless. Even at full volume, it was barely loud enough to make out words in a quiet room from a foot away. If you need sound, plan on using the audio output port, preferably with a powered headset or speakers.

I'd like this projector a lot better if you could use it with a computer by way of VGA or USB Direct Display. But if you have an HDMI port or other digital video output on your computer, or you don't need to use it with a computer, that's not an issue. The projector has a lot to recommend it otherwise, with a usably bright, reasonably high quality image; easy setup; light weight; and long battery life. If you need a highly portable projector for an image source that the 3M Mobile Projector MP300 works with, it's a more than attractive choice.

Source: http://feedproxy.google.com/~r/ziffdavis/pcmag/~3/zEPP0B9_f8I/0,2817,2420713,00.asp

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Appeals court upholds Nintendo victory over IA Labs in patent lawsuit

Companies that prevail in patent lawsuits can't relax until the inevitable appeal is over -- just ask Motorola. Nintendo, however, can take a momentary break. A US Court of Appeals just upheld the company's win over IA Labs, declaring that the Wii Balance Board doesn't infringe on an IA Labs patent. While the ruling isn't all that vital when the accessory is now a rarity at best, it puts IA Labs on the hook for Nintendo's $236,000 attorney bill. It also sends a warning to other companies plotting similar legal assaults, although we'd still expect lawsuits when other patent holders are hitting paydirt.

Filed under: Gaming, Peripherals, Nintendo

Comments

Source: Nintendo

Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/U-bYyvk9b3o/

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What are you most looking forward to in OS X 10.9 Mavericks? [Poll]

iOS 7 wasn't the only star of the show at WWDC 2013, OS X 10.9 Mavericks was officially announced and released to developers the very same day. During the keynote we saw the numerous new features that would be coming to the new version of OS X, including some until now iOS exclusive apps in Apple Maps and iBooks, and a consumer friendly approach to password management with the new iCloud Keychain. But, we want to hear from you guys; what are you most looking forward to in OS X 10.9 Mavericks?

There's a lot to choose from too; improvements to Notification Center, Apple Maps and iBooks coming to the desktop, Finder tabs and tags, iCloud Keychain and the new version of Safari, multiple display support and so much more besides. So, we've narrowed down a few, with an option for something else entirely. We got some great feedback from you on iOS 7, so now it's time to take a look at OS X 10.9! Drop a vote up top and leave us your thoughts in the comments below!

Source: http://feedproxy.google.com/~r/TheIphoneBlog/~3/NmI4Tuw0IfM/story01.htm

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Genetics of cervical cancer raise concern about antiviral therapy in some cases

Public release date: 19-Jun-2013
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Contact: Andrey Morgun
Andriy.morgun@oregonstate.edu
541-737-3424
Oregon State University

CORVALLIS, Ore. A new understanding of the genetic process that can lead to cervical cancer may help improve diagnosis of potentially dangerous lesions for some women, and also raises a warning flag about the use of anti-viral therapies in certain cases suggesting they could actually trigger the cancer they are trying to cure.

The analysis provides a clearer picture of the chromosomal and genetic changes that take place as the human papillomavirus sometimes leads to chronic infection and, in less than 1 percent of cases, to cervical cancer. It is the first to identify specific genes that are keys to this process.

Researchers say they want to emphasize, however, that the HPV vaccine commonly used by millions of women around the world is perfectly safe if done prior to infection with the virus. The concerns raised by this study relate only to viral therapies or possible use of a therapeutic vaccine after the virus has already been integrated into human cells.

"It's been known for decades that only women with prior infection with HPV get cervical cancer," said Andrey Morgun, an assistant professor and a leader of the study in the OSU College of Pharmacy. "In about 90 percent of cases it's naturally eliminated, often without any symptoms. But in a small fraction of cases it can eventually lead to cancer, in ways that have not been fully understood."

These findings were published recently in Nature Communications by researchers from Oregon State University and a number of other universities or agencies in the United States, Norway and Brazil. Collaborators at OSU included Natalia Shulzhenko, an assistant professor in the OSU College of Veterinary Medicine.

The study found that some pre-cancerous lesions can acquire a higher level of chromosomal imbalances in just a small number of cells. These new features appear to do two things at the same time finally eliminate the lingering virus that may have been present for many years, and set the stage for the beginning of invasive cancer.

So long as the virus is not eliminated, it helps to keep under control viral oncogenes that have been integrated into the patient's genome, researchers said.

"Some of what's taking place here was surprising," Morgun said. "But with continued work it should help us improve diagnosis and early monitoring, to tell which lesions may turn into cancer and which will not."

The study also concludes it could be dangerous to use antiviral treatments or therapeutic vaccines with women whose lesions already show signs of HPV integration.

This may help explain why use of the antiviral drug interferon had inconclusive results in the past, in some studies of its value in treating cervical cancer. Patients with existing HPV lesions may wish to discuss findings of this study with their physicians before starting such treatments, researchers said.

Other researchers using a similar analytical approach also found key driver genes in melanoma, according to the report. This approach may have value in identifying genomic changes that are relevant to a range of malignant tumors, scientists said.

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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Public release date: 19-Jun-2013
[ | E-mail | Share ]

Contact: Andrey Morgun
Andriy.morgun@oregonstate.edu
541-737-3424
Oregon State University

CORVALLIS, Ore. A new understanding of the genetic process that can lead to cervical cancer may help improve diagnosis of potentially dangerous lesions for some women, and also raises a warning flag about the use of anti-viral therapies in certain cases suggesting they could actually trigger the cancer they are trying to cure.

The analysis provides a clearer picture of the chromosomal and genetic changes that take place as the human papillomavirus sometimes leads to chronic infection and, in less than 1 percent of cases, to cervical cancer. It is the first to identify specific genes that are keys to this process.

Researchers say they want to emphasize, however, that the HPV vaccine commonly used by millions of women around the world is perfectly safe if done prior to infection with the virus. The concerns raised by this study relate only to viral therapies or possible use of a therapeutic vaccine after the virus has already been integrated into human cells.

"It's been known for decades that only women with prior infection with HPV get cervical cancer," said Andrey Morgun, an assistant professor and a leader of the study in the OSU College of Pharmacy. "In about 90 percent of cases it's naturally eliminated, often without any symptoms. But in a small fraction of cases it can eventually lead to cancer, in ways that have not been fully understood."

These findings were published recently in Nature Communications by researchers from Oregon State University and a number of other universities or agencies in the United States, Norway and Brazil. Collaborators at OSU included Natalia Shulzhenko, an assistant professor in the OSU College of Veterinary Medicine.

The study found that some pre-cancerous lesions can acquire a higher level of chromosomal imbalances in just a small number of cells. These new features appear to do two things at the same time finally eliminate the lingering virus that may have been present for many years, and set the stage for the beginning of invasive cancer.

So long as the virus is not eliminated, it helps to keep under control viral oncogenes that have been integrated into the patient's genome, researchers said.

"Some of what's taking place here was surprising," Morgun said. "But with continued work it should help us improve diagnosis and early monitoring, to tell which lesions may turn into cancer and which will not."

The study also concludes it could be dangerous to use antiviral treatments or therapeutic vaccines with women whose lesions already show signs of HPV integration.

This may help explain why use of the antiviral drug interferon had inconclusive results in the past, in some studies of its value in treating cervical cancer. Patients with existing HPV lesions may wish to discuss findings of this study with their physicians before starting such treatments, researchers said.

Other researchers using a similar analytical approach also found key driver genes in melanoma, according to the report. This approach may have value in identifying genomic changes that are relevant to a range of malignant tumors, scientists said.

###

---

[ | E-mail | Share ]

?

AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Source: http://www.eurekalert.org/pub_releases/2013-06/osu-goc061913.php

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Hope Solo?likely to get?1st start since surgery

By TOM CANAVAN

AP Sports Writer

Associated Press Sports

updated 6:50 p.m. ET June 18, 2013

MONTCLAIR, N.J. (AP) - Hope Solo appears ready to return to the starting lineup for the United States women's soccer team.

While Tom Sermanni isn't ready to say whether Solo will start Thursday against South Korea at Red Bull Arena in Harrison, N.J., the U.S. coach said Tuesday that just having his goaltender - less than four months after having wrist surgery - back on the field is a plus for his team.

It showed last weekend, when Solo played for the first time since appearing in a game against Scotland in February.

Taking over in the second half of a 4-1 win over South Korea at Foxborough, Mass., on Saturday night, the 31-year-old and two-time Olympic gold medalist returned in style. With the U.S. leading 2-1, Solo dove to her right and pushed a shot by Ji Soyun.

"It's just her presence," Sermanni said of Solo. "She was barely on the field for a minute the other night and came up with a fantastic save. That's the kind of thing that sets her apart from a lot of other goalkeepers and makes her probably No. 1 in the world. She has done especially well with her rehab to get back this quick and just having her presence gives everybody a lift, and raises that level of confidence another step."

Solo believes she still has a long way to go to get her left wrist back to 100 percent. The good news is that she still has about two years to get ready for the 2015 World Cup.

"Everything is average or above average, but I want to be great, whether it's distribution, left foot, right foot, my technique catching, diving," Solo said after the team finished a two-plus hour workout at Montclair State University. "All across the board, I want my game to be the best it can be.

"Right now, I am OK."

Solo said 2012 has been somewhat of a slow year after winning the gold medal at the Olympics in London. Even the 10-game tour after winning gold, the team wasn't working on much.

"Maybe we were drinking too much. Maybe we were going on vacation," she said. "That's what people tend to do. You take yourself away and you come out driven and ready to work hard leading into the next event. I think everyone is getting back into things."

To some, the comments might sound controversial. That's Solo though. She has spoken her mind throughout her career, whether it was not playing in a World Cup game in 2007, or pondering the conduct of some fans. She is refreshingly blunt.

The United States has been impressive in this so-called off year. The team is 8-0-2 in 2013, and the game on Thursday will be the last until September. The women will bring a 33-game unbeaten streak into the contest and a 71-game home unbeaten streak.

Solo smiled when asked about her return, including the big save right off the bat.

"Yeah, goalkeepers want to make saves," she said. "At the same time, I have so much more respect for the game now. I feel like I am involved in the game when I am organizing our defense (or) when I am coming out for crosses. I don't need that big-time save to feel like I am a part of the game. My bread and butter is coming out for crosses in a pack of people and our one-vs.-ones.

"At the end of the day, what happens in the 89th minute or the first minute, I think - at this level - I have to stay focused for the entire 90-some minutes."

The wrist still gives Solo some problems, but it is nothing in comparison to the shoulder surgery and rehab she underwent in 2010 to get ready for the World Cup the following year.

"That was the worst agonizing thing I had ever had," Solo said of the eight-hour rehab sessions. "The wrist was a lot easier, so to speak. Now I am feeling pain a lot more and I am trying to figure out exactly how to tape it. My strength isn't where it should be, but I am overall pleased with the surgery."

Solo laughed when asked if she knew whether she would start Thursday since Sermanni deferred to goaltending coach Paul Rogers.

"Maybe," she said, "he'll tell us before the game."

? 2012 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

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All signs point to Brazil

PST: Jozy Altidore scored in a fourth straight game and the United States beat Honduras in World Cup qualifying to stay atop the group.

Robyn Beck / AFP/Getty Images

Source: http://nbcsports.msnbc.com/id/52245620/ns/sports-soccer/

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Full House Committee Transcripts Reveal What Issa Wanted to Hide (Little green footballs)

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